BUCCAL DRUG DELIVERY
SYSTEM

Submitted by:-
Submitted to :-

Nikhat Tara
Dr. kanchan

M.Pharma
kohli (Pharmaceutics)

SPER, JAMIA
HAMDARD

WHAT IS BDDS?

Delivery of the drug through buccal mucosa of
oral cavity. Buccal mucosa lines the inner region
of the cheek.

 In biological term, the product is placed between
the upper gingiva(gum) and cheek to treat local
and systemic condition.

ANATOMY OF BUCCAL CAVITY

CHARACTERISTICS

 Should adhere to the site of attachment for a few
hours

 Should release the drug in a controlled fashion

 Should provide drug release in an unidirectional
way toward the mucosa

 Should facilitate the rate and extent of drug
absorption

 Should not cause any irritation or inconvenience
to the patient and

 Should not interfere with the normal functions
such as talking, drinking

ADVANTAGES

 Avoids first pass metabolism

 Avoids acid/enzyme metabolism

 Penetration is faster with respect to skin and
TDDS

 Large surface area with respect to sub-lingual
mucosa

 Good patient compliance with respect to
parentral

 Easy administration and removal in case of
toxicity.

 For unconscious and comatose patient.

DISADVANTAGES

 Low permeability of the buccal membrane

 Smaller surface area.

 The continuous secretion of saliva leads to
subsequent dilution of the drug.

 Swallowing of saliva can also potentially lead to
the loss of dissolved or suspended drug and,
ultimately, the involuntary removal of the dosage
form.

LIMITATIONS

 Drugs which are unstable at buccal pH cannot
be administered.

 Eating and drinking may become restricted.

 There is an ever present possibility of the
patient swallowing the dosage form.

 Over hydration may leads to slippery surface
and formulation may get disrupted .

 Only drug with small dose requirement can be
administered.

 Drugs contained in the swallowed saliva follow
the pre-oral and advantages of buccal route are
lost.

DRUG DELIVERY PATHWAYS

Transcellular – route for lipophillic drug
Paracellular- route for hydropjillic drug

MUCOADHESION

 Mucoadhesion is the key element.

 The term mucoadhesive is commonly used for the
material that bind to the mucin layer of biological
membrane.

PATHWAYS OF BDDS

PATHWAYS OF BUCCAL DRUG DELIVERY

SYSTEM

BASIC COMPONENTS OF BUCCAL
BIOADHESIVE DRUG DELIVERY
SYSTEM

 Drug substance

 Bioadhesive polymers

 Backing membrane

 Penetration enhancers

 Adhesives

DRUG SUBSTANCE

 The selection of suitable drug for the design of
buccoadhesive drug delivery systems should be
based on pharmacokinetic properties. The drug
should have following characteristics:

 The conventional single dose of the drug should
be small.

 The drugs having biological half-life between 2-8
hours are good candidates for controlled drug
delivery.

 The drug absorption should be passive when
given orally.

BIOADHESIVE POLYMERS

 It should be inert and compatible with the
environment

 • The polymer and its degradation products
should be non-toxic absorbable from the mucous
layer.

 • It should adhere quickly to moist tissue surface
and should possess some site specificity.

 • The polymer must not decompose on storage or
during the shelf life of the dosage form.

 • The polymer should be easily available in the
market and economical.

 • It should allow easy incorporation of drug in to
the formulation

BACKING MEMBRANE

 Backing membrane plays a major role in the
attachment of bioadhesive devices to the mucus
membrane.

 The materials used as backing membrane should
be inert, and impermeable to the drug and
penetration enhancer.

 The commonly used materials in backing
membrane include carbopol, magnesium
stearate, HPMC, HPC, CMC, polycarbophil etc.

PENETRATION ENHANCERS

 Penetration enhancer’s are used in buccoadhesive
formulations to improve the release of the drug.

 They aid in the systemic delivery of the drug by
allowing the drug to penetrate more readily into
the viable tissues.

 The commonly used penetration enhancers are
sodium lauryl sulphate, CPC, polysorbate -80,
laureth -9, sodium fusidate, polmitoyl carnitine,
azone, sodium glycocholate, dimethyl formamide
etc

BUCCAL FORMULATION

Buccal patches
Buccal tablet  It consists of:-
 Tablet are small,  a laminates

flat and oval with consisting of an
a diameter of impermeable
approximately 5- backing layer.
8mm.  a drug containing

 It can be applied reservior layer.
to different site in  Bioadhesive for
oral cavity. mucosal damage

 Drawback:-  Baking layer control
lack of flexibility, the direction,
poor patient prevent drug loss,

compliance minimize
deformation and
disintegration

BUCCAL BILAYER TABLET

BUCCAL PATCHES

BUCCAL FILM

BUCCAL GEL

Buccal film Buccal gels
 Most recently  Semisoid

developed dosage form,
dosage form have the
for buccal advantage of
administration easy

 Prefered over dispersion
adhesive tablet throughout the
in terms of oral mucosa
flexibility and  Maynot be as
comfort. acurate as

 Flexible, tablet, patches
elastic and and film.
soft, yet
adequately
strong.

 Effective in
oral dose

MARKETED FORMULATION