BUCCAL DRUG DELIVERY
Submitted to :-
WHAT IS BDDS?
Delivery of the drug through buccal mucosa of
oral cavity. Buccal mucosa lines the inner region
of the cheek.
In biological term, the product is placed between
the upper gingiva(gum) and cheek to treat local
and systemic condition.
ANATOMY OF BUCCAL CAVITY
Should adhere to the site of attachment for a few
Should release the drug in a controlled fashion
Should provide drug release in an unidirectional
way toward the mucosa
Should facilitate the rate and extent of drug
Should not cause any irritation or inconvenience
to the patient and
Should not interfere with the normal functions
such as talking, drinking
Avoids first pass metabolism
Avoids acid/enzyme metabolism
Penetration is faster with respect to skin and
Large surface area with respect to sub-lingual
Good patient compliance with respect to
Easy administration and removal in case of
For unconscious and comatose patient.
Low permeability of the buccal membrane
Smaller surface area.
The continuous secretion of saliva leads to
subsequent dilution of the drug.
Swallowing of saliva can also potentially lead to
the loss of dissolved or suspended drug and,
ultimately, the involuntary removal of the dosage
Drugs which are unstable at buccal pH cannot
Eating and drinking may become restricted.
There is an ever present possibility of the
patient swallowing the dosage form.
Over hydration may leads to slippery surface
and formulation may get disrupted .
Only drug with small dose requirement can be
Drugs contained in the swallowed saliva follow
the pre-oral and advantages of buccal route are
DRUG DELIVERY PATHWAYS
Transcellular – route for lipophillic drug
Paracellular- route for hydropjillic drug
Mucoadhesion is the key element.
The term mucoadhesive is commonly used for the
material that bind to the mucin layer of biological
PATHWAYS OF BDDS
PATHWAYS OF BUCCAL DRUG DELIVERY
BASIC COMPONENTS OF BUCCAL
BIOADHESIVE DRUG DELIVERY
The selection of suitable drug for the design of
buccoadhesive drug delivery systems should be
based on pharmacokinetic properties. The drug
should have following characteristics:
The conventional single dose of the drug should
The drugs having biological half-life between 2-8
hours are good candidates for controlled drug
The drug absorption should be passive when
It should be inert and compatible with the
• The polymer and its degradation products
should be non-toxic absorbable from the mucous
• It should adhere quickly to moist tissue surface
and should possess some site specificity.
• The polymer must not decompose on storage or
during the shelf life of the dosage form.
• The polymer should be easily available in the
market and economical.
• It should allow easy incorporation of drug in to
Backing membrane plays a major role in the
attachment of bioadhesive devices to the mucus
The materials used as backing membrane should
be inert, and impermeable to the drug and
The commonly used materials in backing
membrane include carbopol, magnesium
stearate, HPMC, HPC, CMC, polycarbophil etc.
Penetration enhancer’s are used in buccoadhesive
formulations to improve the release of the drug.
They aid in the systemic delivery of the drug by
allowing the drug to penetrate more readily into
the viable tissues.
The commonly used penetration enhancers are
sodium lauryl sulphate, CPC, polysorbate -80,
laureth -9, sodium fusidate, polmitoyl carnitine,
azone, sodium glycocholate, dimethyl formamide
Buccal tablet It consists of:-
Tablet are small, a laminates
flat and oval with consisting of an
a diameter of impermeable
approximately 5- backing layer.
8mm. a drug containing
It can be applied reservior layer.
to different site in Bioadhesive for
oral cavity. mucosal damage
Drawback:- Baking layer control
lack of flexibility, the direction,
poor patient prevent drug loss,
BUCCAL BILAYER TABLET
Buccal film Buccal gels
Most recently Semisoid
developed dosage form,
dosage form have the
for buccal advantage of
Prefered over dispersion
adhesive tablet throughout the
in terms of oral mucosa
flexibility and Maynot be as
comfort. acurate as
Flexible, tablet, patches
elastic and and film.