Drugs that act on bones are used in the management of various bone disorders such as osteoporosis, Paget’s disease, and cancer bone metastases. The drugs function by either increasing bone formation or decreasing bone breakdown to enhance overall bone health. Some drugs work by inhibiting the activity of osteoclasts, which are the cells responsible for breaking down and resorbing bone tissue. This process increases bone mineral density and reduces the risk of fractures. Other drugs stimulate the function of osteoblasts, the cells that form new bone tissue. This aids in bone regeneration and healing. Additionally, drugs such as bisphosphonates, calcitonin, and denosumab can reduce bone pain and help prevent bone fractures.
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