G-Protein couple receptor hand written notes pdf

G-Protein couple receptor hand written notes pdf




G-Protein couple receptor hand written notes pdf


A protein-coupled receptor (GPCR) is a type of cell membrane receptor that is involved in a wide range of physiological processes, including sensory perception, hormone regulation, and neurotransmission. GPCRs are the largest family of membrane receptors and are found in almost every cell type in the body.

The structure of GPCRs consists of a single polypeptide chain that is composed of seven transmembrane domains connected by three extracellular and three intracellular loops. The amino-terminal domain is typically located outside the cell, while the carboxy-terminal domain is typically located inside the cell.

When a ligand, such as a hormone or neurotransmitter, binds to the extracellular domain of the GPCR, it causes a conformational change in the receptor that activates a signaling pathway inside the cell. This pathway can involve the activation of intracellular proteins, such as G proteins or second messengers, which then trigger a cascade of downstream effects that ultimately lead to a cellular response.

The diverse range of physiological processes that GPCRs are involved in makes them important targets for drug development. In fact, over 30% of all drugs on the market target GPCRs, including drugs used to treat conditions such as hypertension, asthma, and Parkinson’s disease.Lacture notes downloading, Hand written notes, Pharmacy notes, MBBS notes, Study material, Dental study material, study material PDF, study material PPT, study Lacture notes, Study science notes, Drugs name, free study material PPT, PDF download Free, paramedical study notes

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