Industrial Pharmacy 1 Nirali Prakashan PDF download

A Text Book of

INDUSTRIAL PHARMACY – I

[FORMULATIVE PHARMACY]

As Per PCI Regulations

Third Year B. Pharm.

Semester – V

 Dr. B. Prakash Rao S. Rajarajan 

M.Pharm., Ph.D. M.Pharm. 

Professor in Pharmaceutics, Assistant Professor, 

Acharya and B.M. Reddy College of Pharmacy Department of Pharmaceutics

Bengaluru Karnataka College of Pharmacy

 Bengaluru.

 . 

Dr. Beny Baby 

M.Pharm., Ph.D. 

Associate Professor & H.O.D. 

Department of Pharmaceutics 

Karnataka College of Pharmacy

Bengaluru.

N3997 Preformulation Studies 1.1 – 1.30

 1.1 Introduction 1.1

 1.1.1 Definition 1.1

 1.1.2 Objectives 1.1

 1.1.3 Goals of Preformulation 1.2

 1.1.4 Preformulation Factors 1.2

 1.2 Physical Properties 1.2

 1.2.1 Nature of Solid Drug 1.3

 1.2.2 Solubility Data 1.11

 1.2.3 Stability Analysis 1.14

 1.3 Chemical Properties 1.22

 1.3.1 Hydrolysis 1.22

 1.3.2 Oxidation and Reduction: Second Most Common Way 1.22

 1.3.3 Racemization 1.23

 1.4 Parenteral Dosage Form 1.24

 1.4.1 Routes of Administration of Parenteral Products 1.24

 1.5 Processing of Parenteral Preparation 1.27

 1.5.1 Evaluation of Parenteral Products 1.27

 1.5.2 Objectives of Sterility Testing 1.28

 1.5.3 Steps involved in Sterility Testing 1.28

 1.6 The Biopharmaceutics Classification System (BCS) 1.29

 Questions 1.30

2. Tablets 2.1 – 2.46

 2.1 Introduction 2.1

 2.2 Ideal Characteristics of Tablets 2.2

 2.3 Classification of Tablets 2.3

 2.4 Excipients 2.4

 2.4.1 Fillers/Diluents 2.4

 2.4.2 Binders 2.7

 2.4.3 Disintegrants 2.8

 2.4.4 Lubricants 2.8

 2.5 Formulation of Tablets 2.9

 2.6 Granulation Methods 2.11

 2.6.1 Wet Granulation – [Aqueous Granulation Technique] 2.11

 2.6.2 Dry Granulation – [Non-Aqueous Granulation Technique] 2.13

 2.6.3 Direct Compression 2.14

 2.7 Compression and Processing Problems 2.15

 2.7.1 Capping 2.15

 2.7.2 Lamination 2.16

 2.7.3 Chipping 2.17

 2.7.4 Cracking 2.17

 2.7.5 Sticking