IMP QUESTION
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Modern Pharmaceutics (MAT103T) GTU SEM – 1 IMP QUESTIONS
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Based on the analysis of the GTU 2018- 23 Year exam papers, the top 25 most frequently appearing questions are as follows:
1. Importance of drug-excipient interaction in solid oral dosage form.
2. Write a short note on SMEDDS.
3. What is Preformulation? Explain its significance.
4. Comment on the following: Change in the initial oral drug dose changes the t max.
5. Enlist various parameters affecting Dissolution and describe any one in detail.
6. What is Heckel Plot? Describe its role in tablet physics.
7. Enlist various applications of similarity factor f2 and f1 and ANOVA test in pharmaceutical formulation.
8. Explain: Total Clearance, Volume of distribution.
9. Enlist the model-dependent methods for explaining kinetics of drug release from extended release tablets. Discuss any one
10. Enlist various parameters affecting Dissolution and describe any one in detail.
11. What do you mean by model-dependent method for comparing dissolution profile? Enlist these methods and discuss any one.
12. Enlist the excipients used in large volume parenterals and discuss the formulation of large volume parenteral with respect to industrial perspective.
13. What is Validation? Describe types, scopes, merits of validation.
14. What is calibration? Describe calibration of dissolution apparatus.
IMP QUESTION
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15. What is Qualification? Describe IQ, OQ, PQ
16. Explain cGMP. Describe objectives and policies of cGMP.
17. What is inventory? Write different techniques of Inventory control.
18. Describe Total Quality Management (TQM) in detail.
19. Design a drug excipient interaction study protocol for a film-coated tablet, making suitable assumptions.
20. Explain different theories of dispersion.
21. Enlist various additives used in formulating a parenteral formulation citing suitable detail.
22. What is dose-dependent kinetics? Explain Michaelis-Menten kinetics.
23. Explain the composition of SMEDDS and discuss each in detail.
24. What is optimization? Describe different approaches of the same.
25. Explain in detail response Surface Methodology.
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These questions have appeared frequently across the GTU 2018- 23 Year exam papers, indicating their importance and likelihood of being included in future exams.
Note: –
• 1 to 20 Most IMP
• 21 to 25 Extra for Toppers