Pharmaceutical product development sem 8 (Co-processed excipients) hand written notes pdf

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Co-processed excipients refer to the combination of two or more excipients (inactive ingredients) into a single entity. These excipients are derived from natural sources or are synthesized chemically.

Co-processing is done to enhance the functional and physicochemical properties of excipients, resulting in improved stability, controlled release, solubility, and compressibility.

Co-processed excipients offer numerous advantages over traditional excipients, such as:

1. Cost-effective: The combination of multiple excipients eliminates the need for extra excipients, reducing the total cost.

2. Better functionality: Co-processed excipients provide combined functions, such as lubrication, flow, binding, and disintegration.

3. Improved physical properties: The process of co-processing improves the properties of the excipients, such as particle size, flowability, and compressibility.

4. Improved chemical stability: Co-processed excipients have improved chemical stability, resulting in a longer shelf life.

5. Enhanced drug delivery: Co-processed excipients can improve drug absorption and enhance bioavailability.

Co-processed excipients are commonly used in manufacturing solid dosage forms, such as tablets and capsules. Some examples of co-processed excipients are:

1. Cellactose: It is a combination of microcrystalline cellulose and lactose, used as a diluent and binder in tablet formulations.

2. Prosolv ODT-Gly: It is a combination of croscarmellose sodium, mannitol, and glyceryl behenate, used in oral disintegrating tablets.

3. Ludipress: It is a combination of lactose and pregelatinized maize starch, used as an excipient in tablets and capsules.

4. Starch 1500: It is a combination of pregelatinized potato starch and microcrystalline cellulose, used as a binder and facilitator of tablet disintegration.

In conclusion, co-processed excipients are combinations of two or more excipients used in the manufacturing of drugs to enhance their functional properties. They offer numerous advantages and have become an essential part of pharmaceutical formulation development.