Pharmaceutical product development sem 8 ( non – ionic surfactant) hand written notes pdf

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Non-ionic surfactants are compounds that do not ionize in water and do not contain any charged groups. They are composed of hydrophobic (water-repelling) and hydrophilic (water-attracting) parts. Non-ionic surfactants are widely used in industry and in household products such as laundry detergents, dishwashing liquids, and personal care products.

One of the most common types of non-ionic surfactants is alkyl ethoxylates. These compounds are made by reacting a fatty alcohol or alkylphenol with ethylene oxide. The resulting product is a molecule with a hydrophobic alkyl chain and a hydrophilic ethoxy (EO) chain. The number of EO units in the molecule determines its solubility in water and its ability to form micelles (small clusters of molecules) that can solubilize oils and other nonpolar compounds.

Other types of non-ionic surfactants include alkyl glucosides, fatty acid ethoxylates, and polyethylene glycol (PEG) derivatives. Alkyl glucosides are made by attaching a glucose molecule to a fatty alcohol, while fatty acid ethoxylates are made by reacting a fatty acid with ethylene oxide. PEG derivatives are made by attaching PEG chains to fatty acids or alcohols.

Non-ionic surfactants have several advantages over their ionic counterparts. They are less affected by pH and electrolytes and are less likely to cause skin irritation or damage to fabrics. They also tend to be more biodegradable and environmentally friendly.

However, non-ionic surfactants have some limitations as well. They have lower surface activity and emulsification power compared to ionic surfactants and may require higher concentrations to achieve the desired effects. Additionally, some non-ionic surfactants may be sensitive to temperature and can lose their effectiveness at high or low temperatures.

Overall, non-ionic surfactants are a versatile and important class of compounds that play a critical role in many industrial and consumer applications.