Pharmaceutical product development sem 8 (tablet excipients) hand written notes pdf

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Tablet excipients are the inactive ingredients used in the formulation of tablets. They play a vital role in ensuring the quality, safety, and efficacy of the final product. Here are some of the most commonly used tablet excipients:

1. Binders: Binders hold the ingredients together and improve the tablet’s strength. Common binders include polyvinylpyrrolidone (PVP), hydroxypropyl cellulose (HPC), and methylcellulose.

2. Fillers: Fillers are used to increase the volume of the tablet. They also improve the flow characteristics of the ingredients and prevent segregation during manufacturing. Common fillers are lactose, microcrystalline cellulose (MCC), and dicalcium phosphate.

3. Disintegrants: Disintegrants help to break down the tablet quickly once it enters the stomach. This ensures that the active ingredients are released quickly and absorbed into the bloodstream. Common disintegrants include croscarmellose sodium, sodium starch glycolate, and crospovidone.

4. Lubricants: Lubricants reduce the friction between the tablet and the manufacturing equipment. This allows the tablets to move smoothly during manufacturing, reducing the risk of damage or breakage. Common lubricants include magnesium stearate, stearic acid, and talc.

5. Coatings: Coatings protect the tablet from moisture, sunlight, and other external factors. They also improve the tablet’s appearance, making it easier to swallow. Common coatings include film coatings, sugar coatings, and enteric coatings.

In conclusion, tablet excipients are an essential part of tablet formulation and play a crucial role in ensuring the quality, safety, and efficacy of the final product. The selection of excipients depends on the active ingredient’s properties and the desired tablet characteristics.