Gastroretentive Drug Delivery Systems (GRDDS) are a type of novel drug delivery system that can persist in the stomach for a prolonged period of time, thus increasing the Gastric Residence Time (GRT) of drugs¹². This system is designed to overcome physiological difficulties like short gastric residence times and unpredictable gastric emptying times¹.

The purpose of GRDDS is to accumulate the current literature with a special emphasis on several gastroretentive approaches that have recently become important methodologies in the field of site-specific orally administered sustained/controlled release drug delivery¹².

These systems are particularly beneficial for drugs that are less soluble at an alkaline pH of the intestine, and for drugs that produce their local action in the stomach but get quickly emptied and don’t get sufficient residence time in the stomach¹.

Several efforts have been made to extend the retention time of the drug delivery system to reduce the frequency of dose administration. GRDDS not only prolong dosing intervals but also increase patient compliance beyond the level of existing controlled release dosage