Veterinary pathology: cell injury

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Description

Cellular responses to stress
CAUSES OF CELL INJURY
Mechanism of cell injury
•Definitions
General Considerations
●Common Biochemical mechanism of cell injury
❶ Depletion of ATP
❷Influx of calcium and loss of calcium
homeostasis
❸Mitochondrial Damage and Dysfunction
❹Accumulation of oxygen-derived free
radicals (oxidative stress)
❺ Defects in membrane permeability
❻ Damage to DNA and Proteins

Ischemic and hypoxic cell injury
THE MORPHOLOGY OF CELL AND TISSUE INJURY
Reponses of cell injury
Cellular swelling
Microscopic Appearance