CUSTOMIZED DRUG
DELIVERY SYSTEM

SUBMITTED BY- RUBI PAREEN
M Pharmacy( pharmaceutics)

School Of Pharmaceutical
Education(SPER).

Jamia Hamdard New Delhi.

CONTENT

 introduction.

Advantages of customized drug delivery
system.

Tools to design customized drug delivery
system.

CUSTOMIZED DRUG DELIVERY
SYSTEM

 INTRODUCTION:-

•Drug delivery system that are designed to release the drug
as per the need of the individual or specific patient.

• Therapy with the right drug at right dosing in the right
patient.

•Ability to look at a patient on an individual basis will
allow for a more accurate diagnosis and specific
treatment plan.

•Customized medicines is prepared based on
each patient’s medical history, needs, genetics,
health conditions and other factors.

•Genetic and metabolic data will allow drugs to
be tailored to patient subgroups.

• The customized drug-release profiles required will
necessitate the use of multiple types of technologies
like extended-release, sustained- release & timed-
pulsatile release.

•Much of the innovation will come from developing a
better understanding of the patient rather than the
identification of new molecules

It’s far more
important to know
what person the
disease has than
what disease the
person has.

– Hippocrates

ADVANTAGES OF CUSTOMIZED
MEDICINE

•Better matching patients to drugs instead of “trial and
error”.
•Eliminate life-threating adverse reactions.
•Reduce cost of clinical trials by quickly identifying
total failures & favorable response for particular
backgrounds.
•Improved efficacy of drugs.

•Dosage can be controlled for the patients who need
lower doses or with the needs of each individual
patient.

•Any allergic creating ingredient can be skipped and a
customized medicine can be produced for a
particular individual.

•One size-fits all prescription medicines cannot meet
so customized medications are the only way to better
health.

TOOLS TO CUSTAMIZED DRUG
DELIVERY SYSTEM

Bioelectronic medicines.

3D printing of pharmaceuticals.

BIOELECTRONIC MEDICINES

•New era of medicine.

•New way to understand the language of nervous
system to perform advanced diagnosis.

•A tiny device that is attached to a nerve that would
adjust the electrical signals between the brain & the
organs of our body.

•Bioelectronic medicine is a new approach to treat
and diagnose disease and injury.

 All major organs of the body are innervated,
allowing the brain to both monitor and regulate
organ function.

Bioelectronic medicine uses device technology to
read and modulate the electrical activity within the
body’s nervous system, opening new doors to real-
time diagnostics and treatment options for patients.

Nerve-stimulating or nerve-blocking devices, either
implanted on a nerve have the potential to modulate
specific nerve activity, elicit a specific change in
organ function, and restore health, without the
complicated side effects of pharmaceutical agents.

Such devices are used to treat inflammatory diseases
like as Rheumatoid arthritis & colitis ,Parkinson’s
disease,etc.

This approach is effective and less expensive to
develop than pharmaceuticals, easier to administer,
non-toxic, more precise, 100% compliant, involves
minimal health risks and side effects, and offers an
extensible R&D platform.

3D PRINTING OF
PHARMACEUTICALS

• 3D printing—a type of additive manufacturing
(AM)has the potential to be the “next great step” in
pharmaceutical manufacturing, enabling fabrication
of specialty drugs and medical devices.

• 3D printing can be used for personalized or unique
dosage forms, more complex drug-release profiles,
and printing living tissue.

• 3D printing builds an object layer by layer, it can be
used to print drug tablets with a personalized dosage,
possibly combining multiple drugs into a single
dose.

•Printing a barrier between APIs in a multilayer tablet
could facilitate targeted and controlled drug release.

• 3D printing process could minimize the cost.

• 3D printing could allow these tablets to be made in smaller
lots, as needed, rather than once every few years, which
could improve reproducibility.

• Products that would benefit from the lack of high
compressive forces in 3D printing of tablets

The process involves 3D proto-typing of layer-by-layer
fabrication (via computer-aided design models) to
formulate drug materials into the desired dosage form

Eg. Levetiracetam (SPRITAM) tablets

ADVANTAGES OF 3D PRINTING

•Area of personalized medicines

•Compared to conventional pharmaceutical product
manufacturing process, 3DP offers a lot of attractive
qualities, such as,

• High production rates due to its fast operating systems

•Ability to achieve high drug-loading with much desired
precision and accuracy especially for potent drugs that are
applied in small doses

• Reduction of material wastage which can save in the cost
of production

•Treatment regimens must be customized to improve
patient’s adherence to treatment.

• development and manufacture of single or multi-
drug products with built-in immediate and
controlled-release layers that can be tailored to
unique patient’s situations .

References:

 Lee V K and Dai G, 2017, Printing of three-dimensionaltissue analogs for regenerative
medicine. Ann Biomed Eng, 45(1): 115–131. http://doi.org/ 10.1007/s10439-016-1613-
7

 Knowlton S, Yenilmez B, Anand S, et al., 2017, Photocrosslinking-based bioprinting:
Examining crosslinking schemes. Bioprinting, 5: 10–18. http://doi.org/10.1016/
j.bprint.2017.03.001.