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Education

Education

Education

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Seat No.: _____ Enrolment No. _____________

GUJARAT TECHNOLOGICAL UNIVERSITY
B.Pharm – SEMESTER–VIII • EXAMINATION – WINTER -2021

Subject Code: BP801TT Date: 23/11/2021
Subject Name: Biostatistics and Research Methodology
Time: 10:30 am to 01:30 pm Total Marks: 80
Instructions:

1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Find the Mean, Mode and Median of following data. 06
2, 4, 7, 1, 6, 9, 5, 4, 4, 3, 4

(b) Write a short note on central composite design. 05
(c) Explain in detail of Probability, Binomial distribution. 05

Q.2 (a) Find the Karl Pearson’s coefficient of correlation from the following data. 06
x 5 9 13 17 21
y 12 20 25 33 35

(b) What do you meant by Research? Explain experimental design techniques. 05
(c) What is SPSS? Write down their applications. 05

Q.3 (a) What is hypothesis? What are different types of hypothesis? Explain how you 06
will formulate a hypothesis with a suitable example.

(b) What is meant by regression modeling? Explain hypothesis testing in simple 05
and multiple regression models.

(c) Differentiate SD and SEM. 05

Q.4 (a) Describe the construction of any three types of graphical representation of 06
statistical data with suitable examples.

(b) What do you meant by factorial design? Write some advantages of factorial 05
design.

(c) Explain Blocking and Confounding the 2k factorial design in two blocks. 05

Q.5 (a) Write a note on ANOVA (Analysis of Variance). 06
(b) Explain Wilcoxan signed rank test and Mann Whitney U test. 05
(c) Explain different observational study designs. 05

Q. 6 (a) Explain the following. 06
(i) Cohorts studies
(ii) Report writing and presentation of data

(b) Discuss various phases in designing clinical trial with examples. 05
(c) Define Range and Standard deviation. Find the standard deviation of following 05

data.
1.24, 5.19, 1.62, 9.54, 2.63, 4.25, 5.34

Q.7 (a) Define the following. 06

(i) Null hypothesis and alternative hypothesis
(ii) Error-I type and Error-II type
(iii) Sampling and Essence of Sampling

(b) Classify and explain different types of t tests. 05
(c) What is Plagiarism? What are the needs for research? 05

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Seat No.: _____ Enrolment No. _____________

GUJARAT TECHNOLOGICAL UNIVERSITY
B.Pharm – SEMESTER–VIII • EXAMINATION – WINTER -2021

Subject Code: BP803TT Date: 25/11/2021
Subject Name: Pharma marketing Management
Time: 10:30 am to 01:30 pm Total Marks: 80
Instructions:

1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Seat No.: _____ Enrolment No. _____________

GUJARAT TECHNOLOGICAL UNIVERSITY
B.Pharm – SEMESTER–VIII • EXAMINATION – WINTER -2021

Subject Code: BP809TT Date: 30/11/2021
Subject Name: Cosmetic Science
Time: 10:30 am to 01:30 pm Total Marks: 80
Instructions:

1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Seat No.: _____ Enrolment No. _____________

GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM- SEMESTER VIII – • EXAMINATION – WINTER -2021

Subject Code: BP811TT Date: 25/11/2021
Time: 10:30am to 01:30pm Total Marks: 80
Instructions:

1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Explain: Base peak, Mc lafferty rearrangement, Nitrogen rule in mass 06
spectroscopy.

(b) What is resolution of mass analyzer. Explain briefly time of flight analyzer. 05
(c) Explain working principle of Mass spectrometer with labeled diagram. 05

Q.2 (a) Define chemical shift. Elaborate factors affecting spin-spin coupling. 06
(b) Write a note on instrumentation of NMR. 05
(c) Write a brief overview of C13 NMR spectroscopy. 05

Q.3 (a) Discuss important factors in sample preparation and handling in DTA 06
(b) Describe the principle of TGA and DTA methods. 05
(c) What is the instrumentation and application of DSC? 05

Q.4 (a) Discuss the importance of hyphenated techniques in analysis with special 06
reference to GC-MS/MS.

(b) Discuss instrumentation and applications of X-ray powder diffraction 05
technique.

(c) What is extraction. Give detail note on liquid-liquid extraction technique. 05

Q.5 (a) Explain validation and calibration of UV-Visible spectrophotometer. 06
(b) Discuss calibration of electronic balance. 05
(c) Write note on principle and instrumentation of radio-immunoassay. 05

Q. 6 (a) Write note on solid phase extraction. 06
(b) Explain validation and calibration of HPLC. 05
(c) Write note on fragmentation in MS. 05

Q.7 (a) Write note on HPTLC-MS. 06
(b) Explain advantages and application of RIA. 05
(c) What is x-ray diffraction? Give detail idea about Bragg’s law. 05

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Seat No.: _____ Enrolment No. _____________

GUJARAT TECHNOLOGICAL UNIVERSITY
B.Ph. – SEMESTER– VIII• EXAMINATION – WINTER -2021

Subject Code: BP814TT Date: 30/11/2021
Subject Name: Pharmaceutical Product Development
Time: 10:30am to 01:30pm Total Marks: 80
Instructions:

1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) What is pharmaceutical product development? Give the objectives of 06
pharmaceutical product development in details

(b) Write a note on Cyclodextrins and their applications in solid dispersion. 05
(c) Give detail classification of directly compressible adjuvants with examples. 05

Q.2 (a) Explain Non – ionic surfactants and their applications as emulsifier. 06
(b) Discuss the role of various excipients used in parentral Preparation 05
(c) Explain various elements of QbD. 05

Q.3 (a) Explain the role of various excipients used in aerosol preparation. 06
(b) Write a note on risk assessment methodology with its tools. 05
(c) Explain in details: Excipients use for formulation of NDDS. 05

Q.4 (a) Explain factorial design with example. 06
(b) Give manufacturing and quality control testing of Liquid Dosage form. 05
(c) Discuss in details various Semi solid excipients with examples. 05