Inflammation and
Repair
Types of Inflammation
❶ Acute inflammation
❷ Chronic inflammation
The Cardinal Signs
• Cardinal – Most important; Chief; Principal
❶Rubor (redness)
❷Tumor (swelling)
❸Calor (heat)
❹Dolor (pain)
❺Functio laesa (Loss of function) – Rudolf Virchow
Vascular changes
❶Dilation of small vessels leading to an increase in blood
flow
❷Increased permeability of the microvasculature
enabling plasma proteins and leukocytes to leave the
circulation, and
Cellular events
❸Emigration of the leukocytes from the microcirculation,
their accumulation in the focus of injury, and their
activation to eliminate the offending agent
Phagocytosis
MEDIATORS OF INFLAMMATION
MORPHOLOGIC PATTERNS OF
ACUTE INFLAMMATION
Cellular Components of Inflammation