MPH102T GTU SEM 1 2018-23 Qustion paper M.pharm Drug Delivery System

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Seat No.: _____ Enrolment No. _____________

GUJARAT TECHNOLOGICAL UNIVERSITY
M. Ph.- SEMESTER– I EXAMINATION – WINTER-2018

Subject Code:MPH102T Date: 03/01/2019
Subject Name: Drug Delivery System
Time: 10:30AM TO 1:30 PM Total Marks: 80
Instructions:

1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Explain basic concepts, advantages and disadvantages of controlled release dosage 06
forms.

(b) Discuss physicochemical & biological approaches for sustained release formulations. 05
(c) Write a note on personalized medicine. 05

Q.2 (a) Classify polymers. Discuss biodegradable polymers in detail. 06
(b) Discuss mechanism of drug delivery from sustained and controlled release 05

formulations.
(c) Discuss the scope of 3D printing in pharmaceutical science. 05

Q.3 (a) Discuss bioelectronic medicines and Telepharmacy in detail. 06
(b) Expain pH activated and enzyme activated drug delivery systems. 05
(c) Explain the principle of mucoadhesive drug delivery system, its advantages and 05

disadvantages.

Q.4 (a) Discuss the suitable excipients for gastro retentive drug delivery system. Discuss 06
rationale for selection of API’s for this approach? Why?

(b) Describe methods of formulation of mucoadhesive drug delivery system and its 05
evaluations.

(c) Discuss recent innovations in GRDDS. 05

Q.5 (a) Discuss barriers of drug permeation through ocular drug delivery systems and how to 06
overcome it.

(b) Write a note on ocular drug delivery systems. 05
(c) Discuss percutaneous absorption through skin. 05

Q. 6 (a) Discuss types of transdermal patches. Explain method of preparation of 06
transdermal patches and its evaluations.

(b) Discuss mucosal and transdermal delivery of vaccines. 05
(c) Describe loading and maintenance dose used in controlled release formulation. 05

Q.7 (a) Write a note on protein and peptide delivery systems. 06
(b) Write a note on Iontophoresis. 05
(c) Discuss feedback regulated drug delivery with examples. 05

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Seat No.: _____ Enrolment No. _____________

GUJARAT TECHNOLOGICAL UNIVERSITY
M. PHARM – SEMESTER–I • EXAMINATION – SUMMER -2018

Subject Code: MPH102T Date: 05/05/2018
Subject Name: DRUG DELIVERY SYSTEM
Time: 02:30PM TO 05:30PM Total Marks: 80

Instructions:

1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Discuss the suitable excipients for osmotic drug delivery system. Which API’s 06
can be formulated by this approach? Why?

(b) Discuss feedback regulated drug delivery with examples. 05
(c) What is the scope of 3D printing in pharmaceutical science? 05

Q.2 (a) List out the factors affecting the designing of oral sustained release drug delivery 06
system and discuss any one in detail to formulate it.

(b) Discuss details on tailor made drug delivery system. 05
(c) Explain details on Bioelectronics medicines. 05

Q.3 (a) Discuss about ophthalmic controlled release system. 06
(b) What are the limitations of protein drug delivery? Explain with suitable 05

examples.
(c) Discuss about osmotic dosage forms I) advantages II) mechanism of drug release. 05

Q.4 (a) Discuss formulation and evaluation of protein and peptide delivery. 06
(b) Discuss approaches for osmotic drug delivery system. 05
(c) Discuss limitations of buccal delivery system. Give a detail about mucoadhesive 05

polymers for buccal delivery.

Q.5 (a) What are the Effective strategies for vaccine delivery? Write regarding storage, 06
delivery, its uptake & risk associated with vaccine delivery.

(b) Describe recent innovations in GRDDS. 05
(c) Discuss the influence of excipients in the formulation of gastro retentive drug 05

delivery systems.

Q. 6 (a) Which categories of drugs are suitable for GRDDS, Justify? Discuss in vitro and 06
in vivo evaluations of GRDDS.

(b) Discuss about Biodegradable polymers used in formulation of controlled drug 05
delivery system.

(c) Discuss formulation and evaluation of transdermal drug delivery system. 05

Q.7 (a) Discuss pH activated, mechanical activated, enzymatic activated in drug delivery 06
system.

(b) Describe loading and maintenance dose used in controlled release formulation. 05
(c) Discuss on dissolution and diffusion controlled release system. 05

***************
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Seat No.: _____ Enrolment No. _____________

GUJARAT TECHNOLOGICAL UNIVERSITY
M.PHARM – SEMESTER–1 EXAMINATION – WINTER-2019

 

Subject Code: MPH102T Date: 30/12/2019
Subject Name: Drug Delivery System
Time: 02:30 PM TO 05:30 PM Total Marks: 80

Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Enlist the importance of protein and peptides in Pharmaceuticals. Discuss in vitro and in 06
vivo problems associated with such delivery system.

(b) Which are the potential sites for bio adhesion? Draw a classical diagram of BDDS. Write 05
a note on characterization of this system.

(c) Define muco adhesion. Describe the mechanisms of bio adhesion. 05
Q.2 (a) Discuss the relevant physicochemical properties influencing the development of Sustain 06

release Drug Delivery System.
(b) What is the scope of 3D printing in Pharmaceutical Science? 05
(c) Write short notes on Biodegradable polymers. 05

Q.3 (a) Enlist various properties of polymer. Briefly describe the importance of Molecular 06
weight and Glass transition temperature of polymers. Discuss the method of
determining molecular weight of polymers.

(b) Write about applications of hydrogel in drug delivery system. 05
(c) Mention the suitability of drugs for GRDDS. Explain the altered density approach. 05

Q.4 (a) Differentiate Rate Programmed, Activation Modulated, Feedback Regulated and Site 06
Targeting Drug Delivery System with suitable diagrams.

(b) Classify the Physical, Chemical and Biochemical means of Activation Modulated Drug 05
Delivery system

(c) Explain the pH activated drug delivery. 05
Q.5 (a) Briefly explain the concept of PEGylation and its use in delivering peptide. 06

(b) State the types of Osmotic systems suitable to deliver the soluble drugs and explain the 05
same.

(c) Differentiate Erodible and Non erodible Ocular delivery systems. 05
Q. 6 (a) What are permeation enhancers? Which formulations require excipients to enhance 06

penetration? Give a brief account on penetration enhancer.
(b) Write short notes on methods of evaluating Transdermal delivery systems. 05
(c) Explain Bio erosion regulated and Bio responsive drug delivery with suitable examples 05

and diagram.
Q.7 (a) Differentiate Polymer Membrane Permeation and Polymer Matrix Diffusion Controlled 06

Drug Delivery.
(b) Enumerate bio electronic medicines. 05
(c) Write short notes on Single shot vaccines. 05

***************

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Seat No.: _____ Enrolment No. _____________

GUJARAT TECHNOLOGICAL UNIVERSITY
M.PHARM – SEMESTER–1 EXAMINATION – SUMMER-2019

Subject Code: MPH102T Date: 30/05/2019
Subject Name: Drug Delivery System
Time: 02:30 PM TO 05:30 PM Total Marks: 80
Instructions:

1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Differentiate sustained, controlled and modified drug release giving suitable 06
example.

(b) Enlist physico-chemical approaches for controlled release formulation and 05
discuss any one in details.

(c) Enlist advantages and disadvantages of bioelectronic medicines in 05
pharmaceuticals.

Q.2 (a) Discuss concept of osmotic activated drug delivery system giving suitable 06

examples.
(b) Enlist advantages and disadvantages of pH activated drug delivery system 05

giving suitable example.
(c) Discuss mechanism of enzyme activated drug delivery system. 05

Q.3 (a) Discuss advantages, disadvantages and applications of gastro-retentive drug 06
delivery system giving suitable example.

(b) Enlist various drug permeation used in pharmaceuticals and discuss its 05
importance.

(c) Enlist evaluation parameters of buccal drug delivery system and discuss any 05
two in details.

Q.4 (a) Enlist advantages, disadvantages and applications of TDDS. 06

(b) Discuss any one approach used to prepare TDDS in details. 05
(c) Enlist various evaluation parameters of TDDS and discuss any two in details. 05

Q.5 (a) Enlist and discuss various applications of protein and peptide drug delivery 06
system giving suitable example.

(b) Enlist various formulation approaches for macromolecules and discuss any one 05
in details.

(c) Enlist various evaluation parameters for protein and peptide drug delivery 05
system and discuss any two in detail.

Q. 6 (a) Define loading and maintenance dose and show its calculation to prepare 06

sustained release formulations.
(b) Discuss diffusion and dissolution controlled release system. 05
(c) Discuss any one innovation in ophthalmic drug delivery system in details. 05

Q.7 (a) Discuss objectives and applications of vaccine giving suitable example. 06
(b) Enlist advantages and disadvantages of 3D printing technology used in 05

pharmaceuticals.
(c) Discuss telepharmacy. 05

***************

www.DuloMix.com

 

Seat No.: _____ Enrolment No. _____________

GUJARAT TECHNOLOGICAL UNIVERSITY
M.PHARM – SEMESTER–1 EXAMINATION – SUMMER-2019

Subject Code: MPH102T Date: 30/05/2019
Subject Name: Drug Delivery System
Time: 02:30 PM TO 05:30 PM Total Marks: 80
Instructions:

1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Differentiate sustained, controlled and modified drug release giving suitable 06
example.

(b) Enlist physico-chemical approaches for controlled release formulation and 05
discuss any one in details.

(c) Enlist advantages and disadvantages of bioelectronic medicines in 05
pharmaceuticals.

Q.2 (a) Discuss concept of osmotic activated drug delivery system giving suitable 06

examples.
(b) Enlist advantages and disadvantages of pH activated drug delivery system 05

giving suitable example.
(c) Discuss mechanism of enzyme activated drug delivery system. 05

Q.3 (a) Discuss advantages, disadvantages and applications of gastro-retentive drug 06
delivery system giving suitable example.

(b) Enlist various drug permeation used in pharmaceuticals and discuss its 05
importance.

(c) Enlist evaluation parameters of buccal drug delivery system and discuss any 05
two in details.

Q.4 (a) Enlist advantages, disadvantages and applications of TDDS. 06

(b) Discuss any one approach used to prepare TDDS in details. 05
(c) Enlist various evaluation parameters of TDDS and discuss any two in details. 05

Q.5 (a) Enlist and discuss various applications of protein and peptide drug delivery 06
system giving suitable example.

(b) Enlist various formulation approaches for macromolecules and discuss any one 05
in details.

(c) Enlist various evaluation parameters for protein and peptide drug delivery 05
system and discuss any two in detail.

Q. 6 (a) Define loading and maintenance dose and show its calculation to prepare 06

sustained release formulations.
(b) Discuss diffusion and dissolution controlled release system. 05
(c) Discuss any one innovation in ophthalmic drug delivery system in details. 05

Q.7 (a) Discuss objectives and applications of vaccine giving suitable example. 06
(b) Enlist advantages and disadvantages of 3D printing technology used in 05

pharmaceuticals.
(c) Discuss telepharmacy. 05

***************

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Seat No.: _____ Enrolment No. _____________

GUJARAT TECHNOLOGICAL UNIVERSITY
M.PHARM – SEMESTER–1 EXAMINATION – SUMMER-2020

Subject Code:MPH102T Date: 05/11/2020
Subject Name: Drug Delivery System
Time: 10:30AM TO 1:30 PM Total Marks: 80
Instructions:

1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) What is customized drug delivery? which are the parameters to be considered 06
for personalized medication?

(b) What is telepharmacy? Discuss its advantages and drawbacks. 05
(c) What is 3D printing? Explain 3D printing for pharmaceuticals. 05

Q.2 (a) Describe rationale for developing colon targeted drug delivery system. Explain 06
pH dependent system.

(b) Write note on pulsatile drug delivery systems. 05
(c) Discuss different depot types of controlled release formulations. 05

Q.3 (a) Enlist basic components of osmotic drug delivery system. Describe L-OROS. 06
(b) Enlist modified drug release capsule. Describe Pulsincap approach. 05
(c) What is transmucosal drug delivery? Describe merits, demerits and limitations 05

of transmucosal drug delivery.

Q.4 (a) Which are various approaches of GRDDS? Describe expandable approach. 06
(b) What is chronotherapy? Describe chronotherapy with suitable drug examples. 05
(c) What is polymer? Describe characterization of polymers in detail. 05

Q.5 (a) Describe limitations of conventional occular dosage forms. Explain modern 06
approches for the occular drug delivery.

(b) Describe biodegradable polymers used in pharmaceuticals with suitable 05
examples

(c) Explain pegylation with its advantages. Discuss challenges in pegylation. 05

Q. 6 (a) What are nanocarriers? Discuss their applications in pharmacy with examples. 06
(b) Differentiate between phonophoresis and iontophoresis for enhanced TDDS. 05
(c) What is liposome? Explain depo-foam technology with advantages. 05

Q.7 (a) What are the challenges in protein and peptide drug delivery? Describe 06
different approaches to improve their delivery.

(b) Classify vaccines. Describe mucosal and transdermal delivery of vaccines. 05
(c) Comment: biosimilar development is more challenging than generic 05

development.

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Seat No.: _____ Enrolment No. _____________

GUJARAT TECHNOLOGICAL UNIVERSITY
M. Ph.- SEMESTER– I-EXAMINATION – WINTER-2021

Subject Code: MPH102T Date: 14/03/2022
Subject Name: Drug Delivery System
Time: 10:30AM to 01:30PM Total Marks: 80
Instructions:

1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Classify polymers. Discuss nonbiodegradable polymers in detail. 06
(b) Explain the principle of mucoadhesive drug delivery system, its advantages and 05

disadvantages.
(c) Discuss feedback regulated drug delivery with examples. 05

Q.2 (a) Discuss advantages and disadvantages of controlled release dosage forms. 06
(b) Discuss mechanism of drug delivery from modified drug delivery systems. 05
(c) Discuss mechanism of drug permeation in Buccal drug delivery systems. 05

Q.3 (a) Describe bioelectronic medicines and Telepharmacy. 06
(b) Expain mechanically activated and enzyme activated drug delivery systems. 05
(c) Discuss physicochemical & biological approaches for sustained release 05

formulations.

Q.4 (a) Discuss osmotic activated drug delivery systems. Discuss rationale for selection 06
of API’s for this approach? Why?

(b) Describe methods of formulation of mucoadhesive drug delivery system and its 05
evaluations.

(c) Write application of 3D printing in pharmaceutical science. 05

Q.5 (a) What are barriers of drug permeation through ocular drug delivery systems and 06
how to overcome it.

(b) Discuss mucosal and transdermal delivery of vaccines. 05
(c) Describe barriers for protein delivery systems. 05

Q. 6 (a) Discuss types of transdermal patches. Explain method of preparation of 06
transdermal patches and its evaluations.

(b) Write a note on ocuserts. 05
(c) Calculation of loading and maintenance dose used in controlled release 05

formulation.

Q.7 (a) Discuss pH activated drug delivery systems. 06
(b) Discuss the structure of skin with diagram. 05
(c) Discuss customized drug delivery systems. 05

***************

 

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Seat No.: _____ Enrolment No. _____________

GUJARAT TECHNOLOGICAL UNIVERSITY
M. PHARM. SEMESTER– I EXAMINATION – WINTER -2022

Subject Code:MPH102T Date:03/04/2023
Subject Name: Drug Delivery Systems
Time: 02:30PM TO 05:30PM Total Marks: 80
Instructions:

1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Explain customized drug delivery. Describe factors to be considered for 06
developing personalized medication.

(b) What is 3D printing? Explain 3D printing for pharmaceuticals. 05
(c) What is telepharmacy? Discuss advantages and limitations of telepharmacy. 05

Q.2 (a) Describe need for developing colon targeted drug delivery system. Explain time 06
dependent system.

(b) Explain depot formulation. Discuss various depot types of formulations. 05
(c) What is pulsatile drug delivery? Describe with suitable drug examples. 05

Q.3 (a) What is transmucosal drug delivery? Describe merits, demerits and limitations 06
of oromucosal drug delivery.

(b) Describe working principle of osmotic drug delivery system with diagram. 05
(c) Describe Pulsincap approach for modified capsule drug delivery. 05

Q.4 (a) Describe need of GRDDS. Describe floating tablet approach for GRDDS. 06
(b) What is chronotherapy? Describe chronotherapy with suitable drug examples. 05
(c) Explain polymer. Describe biodegradable polymers with examples. 05

Q.5 (a) Explain in situ gels as occular products. Describe ‘occusert’ and ‘lacrisert’. 06
(b) Describe non-biodegradable polymers used in pharmaceuticals. 05
(c) What is pegylation? Discuss advantages and challenges of pegylation. 05

Q. 6 (a) Describe applications of nanocarriers in pharmacy with drug examples. 06
(b) Describe iontophoresis for enhanced transdermal permeation with diagram. 05
(c) What is nioosome? Explain Atri gel technology with advantages. 05

Q.7 (a) Why protein and peptide are not suitable for oral drug delivery? Describe 06
different approaches to improve their delivery.

(b) Why biosimilar development is more challenging than generic development? 05
(c) Classify vaccines. Describe mucosal and transdermal delivery of vaccines. 05

————————————————-***************————————————-

www.DuloMix.com

 

Seat No.: _____ Enrolment No. _____________

GUJARAT TECHNOLOGICAL UNIVERSITY
M. Ph.- SEMESTER– I EXAMINATION – SUMMER-2022

Subject Code: MPH102T Date: 05/09/2022
Subject Name: Drug Delivery System
Time: 10:30am to 01:30pm Total Marks: 80
Instructions:

1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

 

 

www.DuloMix.com

 

Seat No.: _____ Enrolment No. _____________

GUJARAT TECHNOLOGICAL UNIVERSITY
M. Ph.- SEMESTER– I EXAMINATION – SUMMER-2022

Subject Code: MPH102T Date: 05/09/2022
Subject Name: Drug Delivery System
Time: 10:30am to 01:30pm Total Marks: 80
Instructions:

1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

 

 

www.DuloMix.com

 

Seat No.: _____ Enrolment No. _____________

GUJARAT TECHNOLOGICAL UNIVERSITY
M.PHARM – SEMESTER–1 EXAMINATION – SUMMER -2023

Subject Code: MPH102T Date: 07-08-2023
Subject Name: Drug Delivery System
Time: 02:30 PM TO 05:30 PM Total Marks: 80
Instructions:

1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Differentiate between sustained, controlled and modified drug release giving 06
suitable example.

(b) Enlist physico-chemical approaches for sustained release formulation and 05
discuss any one in details.

(c) Enlist applications, advantages and disadvantages of 3D printing technology in 05
pharmaceuticals.

Q.2 (a) Define various enzyme activated drug delivery system giving suitable 06

examples.
(b) Enlist advantages, disadvantages and applications of Osmotic Drug Delivery 05

system giving suitable example.
(c) Discuss mechanism of pH activated drug delivery system. 05

Q.3 (a) Discuss advantages, disadvantages and applications of Buccal Drug Delivery 06
System giving suitable example.

(b) Discuss various mechanism of muco-adhesion. 05
(c) Enlist various approaches of gastro-retentive drug delivery system and discuss 05

any two in details.

Q.4 (a) Discuss role of penetration enhancers in TDDS and classify it. 06
(b) Enlist various approaches of TDDS and discuss any one in details. 05
(c) Enlist various evaluation parameters of TDDS and discuss any two in details. 05

Q.5 (a) Discuss significance of protein and peptide drug delivery system. 06
(b) Enlist various formulation approaches for protein and peptide drug delivery 05

system and discuss any two in details.
(c) Classify various types of vaccine drug delivery system. 05

Q. 6 (a) Describe loading and maintenance dose used in controlled release formulations. 06
(b) Discuss diffusion and dissolution controlled release system. 05
(c) Discuss any one innovation in ocular drug delivery system in details. 05

Q.7 (a) Classify various polymers used in formulation of SR/CR Drug Delivery 06
System.

(b) Enlist various approaches for vaccine drug delivery system and discuss any one 05
in details.

(c) Discuss any one innovation in GRDDS in details. 05

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