Pharmaceutical analysis sem 1 important MCQ pdf

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Modern Pharmaceutical Analysis 

Demo MCQs

Sr. Question with Multiple Choices Answer
1.  Chromatography can be used to separate

A. form mixtures mixtures into
B. change mixture compositions pure substances
C. separate mixtures into pure substances 
D. all of these

2.  Mobile phase can be gas or liquid
A. gas or liquid 
B. solid or liquid
C. only solid 
D. gas only

3.  The fluid exiting a chromatographic column is called the  eluate 
A. eluent  
B. eluate 
C. analyte 
D. elution

4.  To improve a chromatographic separation, you must  Increase the
A. Increase the number of theoretical plates on the column. number of
B. Increase the height of the theoretical plates on the column.  theoretical
C. Increase both the number and the height of the theoretical plates plates on the

on the column. column
D. Decrease both the number and the height of the theoretical plates

on the column
5.  Infrared spectroscopy provides valuable information about Functional

A. Molecular weight groups
B. Melting point 
C. Conjugation
D. Functional groups

6.  A strong signal at 3400 cm–1 in an IR spectrum indicates the presence Alcohol 
A. Alcohol 
B. Ether
C. Carbonyl
D. Amine

7.  In infrared spectroscopy which frequency range is known as the 1400 – 900cm-1 
fingerprint region?  
A.  400 – 1400cm-1 
B. 1400 – 900cm-1 
C.  900 – 600cm-1 
D.  600 – 250cm-1 

8.  What is a chromophore?  A group of
A. A coloured compound atoms in a
B. A group of atoms in compound responsible for electromagnetic compound

radiation responsible for
C. A group of atoms in a compound responsible for the absorption of the absorption of

electromagnetic radiation electromagnetic
D. A group of atoms in coloured compound  radiation

9.  Which of the following is an example of bulk property or general Refractive index
detector in HPLC detector
A. Fluorescence detector
B. Refractive index detector
C. Electrochemical detector
D. UV-Visible detector

10.  Which of the following is used as a carrier gas in gas chromatography Helium
A. Carbon dioxide
B. Oxygen
C. Helium
D. Methane

11.  1H nuclei located near electronegative atoms tend to be ______ Deshielded
relative to 1H nuclei
A. Shielded
B. Deshielded
C. Resonanced
D. Split

12.  Signal splitting in NMR arises from? Spin-spin
A. Shielding effect coupling
B. Spin-spin decoupling
C. Spin-spin coupling
D. Deshielding effecr

13.  The base peak in mass spectrum is? The peak set to
A. The lowest mass peak 100% relative
B. The peak corresponding to the parent ion intensity
C. The highest mass peak
D. The peak set to 100% relative intensity

14.  Which one of the following is necessary for mass spectrometry to Loss of an
occur? electron
A. Loss of an electron
B. Change of alignment of a proton in a magnetic field
C. A molecular vibration
D. Excitation of an electron from the ground state to a higher energy

15.  Column efficiency is measured in terms of number of theoretical Inversely related
plates, which is: to height
A. Inversely related to height equivalent to theoretical plates equivalent to
B. Directly related to the peak width theoretical
C. Directly related to height equivalent to theoretical plates plates

D. Inversely related to the peak width
16.  In a chromatographic separation, which of the following is most Retention time

appropriate for the qualitative identification of a substance?
A. Relative retention factor
B. Retention factor
C. Retention time
D. Resolution

17.  The basis of the technique of chromatography for separating the interaction
components of a mixture is? of the
A. the differing movement of particles of different mass in an components
electrical field with a stationary
B. the interaction of the components with a stationary and a mobile and a mobile
phases phases
C. the absorption of infrared radiation by the components.
D. the deflection of charged particles in a magnetic field.

18.  HPLC is an abbreviation for? High Pressure
A. High Profit Liquid Chromatography Liquid
B. High Pressure Liquid Chromatography Chromatography
C. Higher Performance Low Chromatography
D. Higher Profit Low Chromatography

19.  In IR spectroscopy, the wave number for carbonyl group is observed 1740-1650 cm-1
in the range of
A. 3500-3300 cm-1
B. 2200-2100 cm-1
C. 1740-1650 cm-1
D. 3000-2800 cm-1

20.  Which of the following techniques would be most useful to identify IR
and quantify the presence of a known impurity in a drug substance?

21.  In mass spectrometry, fragmentation of ions is achieved through? Ionization
A. Ionization
B. Splitting
C. Solubilization
D. Coupling

22.  he dipole magnetic moment (μ) is directly proportional to nuclear spin Gyromagnetic
(I), connected by a constant called the ratio (γ)
A. Gyromagnetic ratio (γ) 
B. Planck’s constant (h)
C. Nuclear susceptibility (χ)
D. Chemical shift (δ)

23.  Which of the following names refers to the highest energy spin state Spin-down
of an ¹H nucleus in a magnetic field? 
A. Spin-up

B. Spin-down
C. Parallel
D. |+½>

24.  Chemical shifts (δ) are typically reported in units of Parts per million
A. Gauss (G) (ppm)
B. Millitesla per meter (mT/m) 
C. Parts per million (ppm)
D. Percent (%)

25.  What is shielding in NMR?  When the
A. Using a curved piece of metal to block an opponent’s attack magnetic
B. Putting metal around an Rf source moment of an
C. When the magnetic moment of an atom blocks the full induced atom blocks the

magnetic field from surrounding nuclei full induced
D. Blocking parts of a molecule from Rf radiation magnetic field